36 research outputs found
Why Chromatic Imaging Matters
During the last two decades, the first generation of beam combiners at the
Very Large Telescope Interferometer has proved the importance of optical
interferometry for high-angular resolution astrophysical studies in the near-
and mid-infrared. With the advent of 4-beam combiners at the VLTI, the u-v
coverage per pointing increases significantly, providing an opportunity to use
reconstructed images as powerful scientific tools. Therefore, interferometric
imaging is already a key feature of the new generation of VLTI instruments, as
well as for other interferometric facilities like CHARA and JWST. It is thus
imperative to account for the current image reconstruction capabilities and
their expected evolutions in the coming years. Here, we present a general
overview of the current situation of optical interferometric image
reconstruction with a focus on new wavelength-dependent information,
highlighting its main advantages and limitations. As an Appendix we include
several cookbooks describing the usage and installation of several state-of-the
art image reconstruction packages. To illustrate the current capabilities of
the software available to the community, we recovered chromatic images, from
simulated MATISSE data, using the MCMC software SQUEEZE. With these images, we
aim at showing the importance of selecting good regularization functions and
their impact on the reconstruction.Comment: Accepted for publication in Experimental Astronomy as part of the
topical collection: Future of Optical-infrared Interferometry in Europ
Resolving Decades of Periodic Spirals from the Wolf-Rayet Dust Factory WR 112
WR 112 is a dust-forming carbon-rich Wolf-Rayet (WC) binary with a dusty
circumstellar nebula that exhibits a complex asymmetric morphology, which
traces the orbital motion and dust formation in the colliding winds of the
central binary. Unraveling the complicated circumstellar dust emission around
WR 112 therefore provides an opportunity to understand the dust formation
process in colliding-wind WC binaries. In this work, we present a multi-epoch
analysis of the circumstellar dust around WR 112 using seven high spatial
resolution (FWHM ) N-band ( m) imaging
observations spanning almost 20 years and includes newly obtained images from
Subaru/COMICS in Oct 2019. In contrast to previous interpretations of a face-on
spiral morphology, we observe clear evidence of proper motion of the
circumstellar dust around WR 112 consistent with a nearly edge-on spiral with a
half-opening angle and a -yr period. The revised
near edge-on geometry of WR 112 reconciles previous observations of highly
variable non-thermal radio emission that was inconsistent with a face-on
geometry. We estimate a revised distance to WR 112 of kpc based on the observed dust expansion rate and a
spectroscopically derived WC terminal wind velocity of
km s. With the newly derived WR 112 parameters we fit optically-thin
dust spectral energy distribution models and determine a dust production rate
of M yr, which
demonstrates that WR 112 is one of the most prolific dust-making WC systems
known.Comment: 17 pages, 9 figures, 1 animated gif, accepted for publication in Ap
Resolving Decades of Periodic Spirals from the Wolf–Rayet Dust Factory WR 112
WR 112 is a dust-forming carbon-rich Wolf–Rayet (WC) binary with a dusty circumstellar nebula that exhibits a complex asymmetric morphology, which traces the orbital motion and dust formation in the colliding winds of the central binary. Unraveling the complicated circumstellar dust emission around WR 112 therefore provides an opportunity to understand the dust formation process in colliding-wind WC binaries. In this work, we present a multi-epoch analysis of the circumstellar dust around WR 112 using seven high spatial resolution (FWHM ~ 0farcs3–0farcs4) N-band (λ ~ 12 μm) imaging observations spanning almost 20 yr and that includes images obtained from Subaru/COMICS in 2019 October. In contrast to previous interpretations of a face-on spiral morphology, we observe clear evidence of proper motion of the circumstellar dust around WR 112 consistent with a nearly edge-on spiral with a θ_s = 55° half-opening angle and a ~20 yr period. The revised near edge-on geometry of WR 112 reconciles previous observations of highly variable nonthermal radio emission that was inconsistent with a face-on geometry. We estimate a revised distance to WR 112 of d = 3.39_(-0.84)^(+0.89) kpc based on the observed dust expansion rate and a spectroscopically derived WC terminal wind velocity of v_∞ = 1230 ± 260 km s⁻¹. With the newly derived WR 112 parameters, we fit optically thin dust spectral energy distribution models and determine a dust production rate of Ṁ_d = 2.7_(-1.3)^(+1.0) x 10⁻⁶ M_⊙ yr⁻¹, which demonstrates that WR 112 is one of the most prolific dust-making WC systems known
IL-6, IL-10 and TNF-α gene polymorphisms in preeclampsia: a case-control study in a Mexican population
Objectives: We focused our study on examining the genotype and allele frequency of IL-6 (rs1800795), TNF-α (rs1800629) and IL-10 (rs1800872) single nucleotide polymorphisms (SNP) on preeclampsia (PE) diagnosed Mexican pregnant women. Material and methods: A case-control study was designed including 86 preeclampsia patients and 100 normotensives pregnancies from Women’s Hospital of Culiacan, Mexico. Genotyping of IL-6, TNF-α and IL-10 was performed using TaqMan SNP Genotyping. Results: Not significant association was found between development of PE and genotypic (p > 0.05) and allelic (p > 0.05) frequencies of IL-6, TNF-α and IL-10 SNPs. Genotype distributions of IL-6 (p = 0.599), TNF-α (p = 0.721) and IL-10 (p = 0.761) polymorphisms in the two groups were in agreement with Hardy–Weinberg equilibrium. Conclusions: According to the findings, the IL-6, TNF-α and IL-10 SNPs are not exponents of susceptibility to developing PE
The Near Infrared Imager and Slitless Spectrograph for JWST -- V. Kernel Phase Imaging and Data Analysis
Kernel phase imaging (KPI) enables the direct detection of substellar
companions and circumstellar dust close to and below the classical (Rayleigh)
diffraction limit. We present a kernel phase analysis of JWST NIRISS full pupil
images taken during the instrument commissioning and compare the performance to
closely related NIRISS aperture masking interferometry (AMI) observations. For
this purpose, we develop and make publicly available the custom "Kpi3Pipeline"
enabling the extraction of kernel phase observables from JWST images. The
extracted observables are saved into a new and versatile kernel phase FITS file
(KPFITS) data exchange format. Furthermore, we present our new and publicly
available "fouriever" toolkit which can be used to search for companions and
derive detection limits from KPI, AMI, and long-baseline interferometry
observations while accounting for correlated uncertainties in the model fitting
process. Among the four KPI targets that were observed during NIRISS instrument
commissioning, we discover a low-contrast (~1:5) close-in (~1 )
companion candidate around CPD-66~562 and a new high-contrast (~1:170)
detection separated by ~1.5 from 2MASS~J062802.01-663738.0. The
5- companion detection limits around the other two targets reach ~6.5
mag at ~200 mas and ~7 mag at ~400 mas. Comparing these limits to those
obtained from the NIRISS AMI commissioning observations, we find that KPI and
AMI perform similar in the same amount of observing time. Due to its 5.6 times
higher throughput if compared to AMI, KPI is beneficial for observing faint
targets and superior to AMI at separations >325 mas. At very small separations
(<100 mas) and between ~250-325 mas, AMI slightly outperforms KPI which suffers
from increased photon noise from the core and the first Airy ring of the
point-spread function.Comment: 34 pages, 17 figures, accepted for publication in PAS
The Near Infrared Imager and Slitless Spectrograph for the James Webb Space Telescope -- IV. Aperture Masking Interferometry
The James Webb Space Telescope's Near Infrared Imager and Slitless
Spectrograph (JWST-NIRISS) flies a 7-hole non-redundant mask (NRM), the first
such interferometer in space, operating at 3-5 \micron~wavelengths, and a
bright limit of magnitudes in W2. We describe the NIRISS Aperture
Masking Interferometry (AMI) mode to help potential observers understand its
underlying principles, present some sample science cases, explain its
operational observing strategies, indicate how AMI proposals can be developed
with data simulations, and how AMI data can be analyzed. We also present key
results from commissioning AMI. Since the allied Kernel Phase Imaging (KPI)
technique benefits from AMI operational strategies, we also cover NIRISS KPI
methods and analysis techniques, including a new user-friendly KPI pipeline.
The NIRISS KPI bright limit is W2 magnitudes. AMI (and KPI) achieve
an inner working angle of mas that is well inside the mas
NIRCam inner working angle for its circular occulter coronagraphs at comparable
wavelengths.Comment: 30 pages, 10 figure
Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis
BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London